Whereas, DNMT3A (HR = 1.35, 95% CI [1.09–1.67], p = 0.0064) and DNMT3B (HR = 1.37, 95% CI [1.16–1.63], p = 0.00025) were significantly correlated with prognosis of GC patients (Figs. 5A–5D). The gene discussed is DNMT3A; the disease is gastric cancer.