NDRG2, another member of NDRG family which includes four members NDRG1-4, was reported to be significantly decreased in human cancers, and in GC, H. pylori silenced Ndrg2 by activating the NF-κB pathway and up-regulating DNMT3b, promoting GC progression (Ling, 2015). The gene discussed is NDRG1; the disease is cancer.