For vWF, a ROC analysis was performed to find the best discriminatory cut-off (96.91 AU) for the Kaplan-Meier analysis, where patients with PAH above or equal to the threshold displayed worse survival compared to patients with PAH below the threshold (p = 0.0029) (Figure 2(a) and (b)). This evidence concerns the gene VWF and pulmonary arterial hypertension.