AIFM2 and lung carcinoma: Furthermore, to determine whether inhibition of FSP1 might be clinically relevant to in vivo tumor sensitization to ferroptosis-activated chemotherapy, Bersuker et al. used ferroptosis-resistant H460 lung cancer cells in a preclinical xenograft tumor mouse model generated with GPX4KO and GPX4KO FSP1KO H460 cell lines [48].