OPTN and amyotrophic lateral sclerosis: ALS-related genes include mutations in superoxide dismutase 1, fused in sarcoma (FUS), transactive response DNA-binding protein 43 (TDP-43), C9orf72, optineurin, sequestosome 1, ubiquilin 2, dynactin, MATR3, and valosin-containing protein (VCP) [2].