The overexpression of MUC16 induced by gene mutations was reported to affect LC cells, increasing their resistance to cisplatin and gemcitabine, promoting their growth, and enhancing their migration and invasion by downregulation of p53 (Lakshmanan et al., 2017; Kanwal et al., 2018). The gene discussed is MUC16; the disease is laryngotracheoesophageal cleft.