The top association corresponds to HEXIM1 (p = 1.07 × 10−6), which modulates hypoxia-inducible factor-1 alpha and vascular endothelial growth factor (Ogba et al., 2010; Ketchart et al., 2013), angiogenic factors which may influence stroke risk by mediating neovascularization in atherosclerotic lesions, potentially precipitating thrombi that obstruct blood flow to the brain (Bentzon et al., 2014; Chistiakov et al., 2015; Camaré et al., 2017). The gene discussed is HIF1A; the disease is Stroke.