AKT1 and human papilloma virus infection: The results showed that genes clustered in the yellow module were mainly involved in extracellular structure organization (GO:0006281) (Figure 4B) and were significantly enriched in the human papillomavirus infection (hsa05165) and PI3K-Akt signaling pathway (hsa04151) (Figures 5A,B), which is considered the main tumorigenic pathway for EC.