MTHFR and hypertensive disorder: MTHFR rs1801133 polymorphism was associated to elevated risk of myocardial infarction in young and middle-aged Caucasian individuals (Liew and Gupta, 2015); however, this issue remains controversial showing both association between MTHFR rs1801133 and hypertension and the lack of association (Amrani-Midoun et al., 2016; Ghogomu et al., 2016).