MTHFR and coronary artery disorder: Finally, in relation to MTHFR gene polymorphisms, Maitland-van der Zee et al. (2008) observed that subjects carrying C/C genotype for MTHFR rs1801133 genetic variant exhibited a significantly protective effect against CHD [0.71 (95% CI 0.58–0.87)] when the patients were treated with pravastatin.