IL17A and systemic lupus erythematosus: Although IL17a has not been implicated in systemic reactions to vaccines, increases in systemic IL17a have been associated with disease severity in systemic auto-immune diseases in humans such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis and may be contributing to systemic adverse reactions to C. burnetii WCV as well (39, 41).