In cattle, liver fibrosis has been proposed as a downstream effect of upregulated TNF and IL1B, which would activate the genes that were also upregulated in the bovine study, i.e., IL6, PLAU, SERPINE1, TNFRSF1A, SOCS1, and CTSB (18). The gene discussed is SERPINE1; the disease is Hepatic fibrosis.