Upon flavividae infection, BBB and TJ are often disrupted: infection with West Nile virus and classic swine fever virus both lead to claudin-1 degradation (Medigeshi et al., 2009; Roe et al., 2012; Wang et al., 2021) and Japanese encephalitis virus infection induces the degradation of claudin-5 (Chang et al., 2015). Here, CLDN5 is linked to infection.