In the UUO mouse model of renal fibrosis, genetic ablation of CD8+ T cells increased renal interstitial fibrosis by promoting BM-derived monocyte-to-fibroblast transition, whereas, adaptive transfer of CD8+ T cells to CD8 knockout mice decreased fibrosis, which indicated that CD8+ T cells might have an anti-fibrotic effect on kidneys. The gene discussed is CD8A; the disease is renal fibrosis.