In parenchymal arterioles of mice with angiotensin II (AngII)-induced hypertension, the reduced expression and function of both TRPV4 and SKCa underpin impaired carbachol- and TRPV4 agonist-induced (probably EDH-mediated) vasorelaxation (Diaz-Otero et al., 2018). Here, TRPV4 is linked to hypertensive disorder.