TRPV4 and hypertensive disorder: Taking these results together, it is intriguing to speculate whether decreases in the number of endothelial caveolae during hypertension lead to a loss of both TRPV4 and SKCa in endothelial cells, which in turn impairs the endothelium-dependent, NO- and/or EDH-mediated vasorelaxation in genetic hypertension.