Because increasing the TRPV4 expression using gene delivery by lentiviral vectors restored the reduced TRPV4 agonist- and flow-induced vasorelaxations in aged rats, reduced expression of endothelial TRPV4 appears causally related to the age-associated endothelial dysfunction in this model (Du et al., 2016). Here, TRPV4 is linked to endothelial dysfunction.