Indeed, it has been reported that blood pressure levels positively correlate with some oxidative stress-related parameters in hypertension (Rodrigo et al., 2007), and the higher levels of blood pressure achieved in the study by Ottolini et al. (2019, 2020) might preferentially lead to an increased peroxynitrite formation at MEPs and hence impaired activity of TRPV4. This evidence concerns the gene TRPV4 and hypertensive disorder.