TP53 and Sepsis: This study showed that LcS + geniposide decreased the expression of Ac-FOXO1, Ac-NF-κB, and Ac-p53 in mice with sepsis, confirming that LcS + geniposide affected the expression of Ac-FOXO1, Ac-NF-κB, and Ac-p53 by activating the expression of SIRT1, thereby regulating inflammation and oxidative stress, and even enabling the identification of cognitive dysfunction in mice with sepsis.