LcS + geniposide and dexamethasone exerted stronger effects on these proteins as compared with geniposide, while LcS + geniposide and dexamethasone treatment resulted in Ac-FOXO1, Ac-NF-κB, Ac-p53, and SIRT1 protein expression in mice with sepsis that was closest to that of the normal group. Here, TP53 is linked to Sepsis.