Geniposide, LcS + geniposide, and dexamethasone significantly reduced the TNF-α (176.71 ± 8.31, 99.63 ± 5.39, and 122.86 ± 7.25 pg/mg tissue), IL-6 (11.98 ± 0.34, 6.13 ± 0.17 and 8.94 ± 0.1 pg/mg tissue), and IL-1β (64.16 ± 0.97, 30.54 ± 0.61 and 46.85 ± 1.69 pg/mg tissue) levels in the hippocampi of the mice with sepsis. Here, TNF is linked to Sepsis.