This study showed that LcS + geniposide decreased the expression of Ac-FOXO1, Ac-NF-κB, and Ac-p53 in mice with sepsis, confirming that LcS + geniposide affected the expression of Ac-FOXO1, Ac-NF-κB, and Ac-p53 by activating the expression of SIRT1, thereby regulating inflammation and oxidative stress, and even enabling the identification of cognitive dysfunction in mice with sepsis. Here, SIRT1 is linked to Sepsis.