In this study, we found that LcS promoted the conversion of geniposide into genipin, which reduced the TNF-α, IL-6, IL-1β, and MDA levels in the hippocampi of septic mice, and it increased the activities of SOD and CAT, indicating that the combination of geniposide and LcS decreased the inflammatory response and oxidative stress injury in mice with sepsis, with greater efficacy than geniposide utilized alone. Here, TNF is linked to Sepsis.