FOXO1 and rheumatoid arthritis: Garg et al. (2016b, 2016c) published in vitro and in vivo findings using NLC-mediated delivery of methotrexate that showed a higher expression of the proapoptotic gene, Bim, controlled by nuclear factor-κB (NF-κB) and forkhead box O1 protein (FOXO1), which is supported by the relative mRNA expression (fold regulations) of apoptotic and pro-inflammatory mediators in human U937 and experimental RA models.