Recent pieces of evidence highlighted the potential role of this modulation in MDD and in BPAD, with preclinical studies that demonstrated that reduced Kv3 in PV-INs in the dentate gyrus induced depression phenotypes (Medrihan et al., 2020) and that Kv3.1- and Kv3.2-positive modulators are able to reverse and prevent manic behaviors in mouse models (Parekh et al., 2018). The gene discussed is KCNC1; the disease is depressive disorder.