SIRT1 and neurodegenerative disease: And the inhibition of NAD+-SIRT1-PPARGC1A-UCP2 axis activity, resulting in increased mitochondrial membrane potential, PTEN induced putative kinase 1 (PINK1) cleavage, mitochondrial autophagy deficiency, and accelerating aging phenotype and neurodegenerative diseases, PINK1, as an autophagy-related protein attached to the outer mitochondrial membrane, is transported to the mitochondria in a membrane potential-dependent manner and degraded by mitochondrial protease, thus unable to trigger mitochondrial autophagy (Scheibye-Knudsen et al., 2014).