MAPT and Alzheimer disease: However, it has been recently reported that resveratrol not only reduces the expression of Aβ and p-tau protein in AD model mice, increase the activity of toxic protein degradation pathway, and improve the protein balance between normal mice and AD model mice, but also up-regulate SIRT1-mediated mitochondrial biogenetic pathway and promote the recovery of mitochondrial function and energy supply by increasing the level of AMPK protein (Corpas et al., 2019).