SIRT1 and Alzheimer disease: Recently, scholars have revealed the epigenetic alterations in patients with AD through an integrated multi-omics approach, in which the up-regulation of histone acetyltransferase expression in H3K27ac and H3K9ac leads to an increase in their acetylation level, and the activity and expression of SIRT1 in AD patients are also decreased (Nativio et al., 2020), which leads us to wonder whether restoring histone acetylation levels in patients with AD might reverse epigenetic alterations and provide new therapeutic targets for improving AD?