However, it has been recently reported that resveratrol not only reduces the expression of Aβ and p-tau protein in AD model mice, increase the activity of toxic protein degradation pathway, and improve the protein balance between normal mice and AD model mice, but also up-regulate SIRT1-mediated mitochondrial biogenetic pathway and promote the recovery of mitochondrial function and energy supply by increasing the level of AMPK protein (Corpas et al., 2019). Here, SIRT1 is linked to Alzheimer disease.