In the sensitivity analyses, the associations of APOE ε4, ILAs, and three subtypes of leisure activities with cognitive decline were generally consistent with the main findings reported, after we included depressive symptoms, the function of activities of daily living, and population weights (Supplementary Table 2), dropping from the sample individuals who had moderate or severe cognitive impairment at baseline (Supplementary Table 3). This evidence concerns the gene APOE and Mental deterioration.