TRPM8 and Alzheimer disease: In section 2, we describe our model (the schematic representation of the model is given in Figure 1) in its different components: (i) Ca2+-dependent exosomal release in neurons and in astrocytes, (ii) astrocytic exosome exocytosis mediated by Aβ in AD, and (iii) temperature dependence of neuron models including TRPM8 currents.