Coherent with this idea, the positive modulation of the α7nAChR by cotinine is neuroprotective against amyloid-β peptide (Aβ) toxicity in vivo, inhibiting GSK3β-mediated Tau phosphorylation, and activating the transcription factor CREB (required for long-term memory storage), improved memory abilities in mouse models of AD (Echeverria et al., 2011; Echeverria and Zeitlin, 2012; Patel et al., 2014; Grizzell and Echeverria, 2015; Grizzell et al., 2017). Here, MAPT is linked to Alzheimer disease.