Abbreviations: BUN, blood urea nitrogen; BP, blood pressure; CKD, chronic kidney disease; AKI, acute kidney injury; CHF, congestive heart failure; CCB, Calcium channel blocker; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; n (%), number and percentage of patients; a,b,c,d There is a significant difference between the parameters marked with the same letter (p<0.05). The gene discussed is ACE; the disease is congestive heart failure.