LGALS3 and type 2 diabetes mellitus: Menini et al. [9] has shown Gal-3's significance in initiating and advancing T2DM long-term complications because of its capacity to link both advanced glycation end products (AGEs) and advanced lip-oxidation end products (ALEs) that accumulate in the target organ and exert toxic effects by activating proinflammatory and pro-oxidant pathways.