In this research, the results have shown that the frequency of AA genotype of LGALS-3 rs4652 gene variant was most common among the control group than T2DM without CAD and T2DM with CAD (66.4% > 26.7% > 6.9%), respectively, and the opposite was found in Gal-3 AC and CC genotyping which were higher among T2DM with CAD than T2DM without CAD than the control group (39.3% and 62.5% > 36.4% and 35.0% > 24.3% and 2.5%) respectively. The gene discussed is LGALS3; the disease is type 2 diabetes mellitus.