Importantly, Quinti et al. [25] recently underlined that special consideration should be given to the fact that the risk of being infected by SARS-CoV-2, developing severe COVID-19 illness or displaying prolonged viral shedding, as well as that of experimenting vaccination failure, may be especially magnified in subjects with insufficient serum and/or secretory anti-SARS-CoV-2 IgA response. Here, CD79A is linked to COVID-19.