In left-sided CRCs (Descending colon to rectum), however, we observed a—compared to the other subgroups—notably stronger prognostic impact of CDX2 loss on patient survival in univariate analyses, which was also present in left-sided microsatellite-instable CRCs, arguing that the evaluation of CDX2 expression has its highest relevance in left-sided colorectal carcinomas. The gene discussed is CDX2; the disease is colorectal carcinoma.