CDX2 and neoplasm: When analysed separately in MSS- and MSI-H CRCs in the overall cohort, tumour budding (P < 0.001 for all comparisons in MSS/MSI-H) and CRC subtypes (DSS: P < 0.001 in MSS; P = 0.007 in MSI-H/DFS: P < 0.001 in MSS; P = 0.01 in MSI-H) retained their prognostic impact in both microsatellite subgroups, while comparable to CDX2, WHO grade only remained significant in MSS CRC (P < 0.001 for all comparisons in MSS; P > 0.05 for MSI-H, details Table 3).