Compared to CDX2, which is normally assessed via immunohistochemistry, the recent WHO classification from 2019 defines the different histomorphological subtypes of CRC, tumour budding activity and the traditional WHO-grading algorithm in its essential diagnostic criteria for CRC, which represent purely histomorphological parameters that are assessed through the evaluation of HE-stained slides. This evidence concerns the gene CDX2 and colorectal carcinoma.