CDX2 is also known to be strongly expressed by the majority of neoplasms of the colorectal system and is a marker that is frequently used in the daily practice of surgical pathology to verify or rule out an intestinal and especially colorectal origin of a carcinoma, for example in the setting of suspected CRC metastases in other organs or for histogenetic classification of cancers with unknown primary site [30]. The gene discussed is CDX2; the disease is neoplasm.