In multivariate analyses (including age, gender, UICC stage, MSI-status, WHO grade, tumour budding, CRC subtypes and CDX2 groups) CDX2 expression was not an independent prognostic factor in the overall cohort (DSS: P = 0.97, 5; Table 5; DFS: P = 0.75, Supplementary Table 1; OS: P = 0.61, Supplementary Table 2) and in the subcohorts of UICC Stage II/III CRCs (DFS: P = 0.58; Supplementary Table 3; DSS: P = 0.72, Supplementary Table 4; OS: P = 0.97, Supplementary Table 5) as well as in right-/left-sided CRCs (P > 0.05 for all comparisons, data not shown). This evidence concerns the gene CDX2 and neoplasm.