Notably, when analysed separately within CDX2-high vs CDX2-low/absent tumours, tumour budding/CRC subtypes remained highly prognostic (e.g. DFS: P < 0.001; data not shown) in all CDX2 groups, while WHO grade remained highly prognostic in CDX2-high (e.g. DFS: P < 0.001; data not shown), but not in CDX2-low/absent tumours. Here, CDX2 is linked to neoplasm.