CDX2 and neoplasm: CDX2-low/absent CRCs usually showed a reduced CDX2 staining intensity (CDX2-low/absent: strong staining intensity: 0/102 (0%), medium staining intensity: 24/102 (23%), weak staining intensity: 66/102 (65%), absent staining: 12/102 (12%); CDX2-high: strong staining intensity: 842/901 (94%), medium staining intensity: 59/901 (6%), P < 0.001) and a significantly higher rate of a heterogeneous/absent staining pattern when compared to CDX2-high tumours (CDX2-low/absent: absent: 12/102 (12%), heterogeneous: 90/102 (88%); CDX2-high: heterogeneous: 26/901 (3%), diffuse: 875/901 (97%), P < 0.001).