Our study delivers three key messages: first, loss of CDX2 is of some prognostic relevance in CRC in univariate analyses, but its prognostic power is substantially inferior compared to the morphological factors defined by the WHO classification, especially when certain clinical subcohorts (e.g. UICC Stage II/III) are taken into account and vanishes when these parameters are incorporated into multivariate analyses. This evidence concerns the gene CDX2 and colorectal carcinoma.