In order to address these questions, we evaluated CDX2 expression in a large cohort of over 1000 CRCs and analysed its connection to tumour budding, WHO grade and the various histomorphological CRC subtypes and compared the impact of all factors in the overall cohort, specific stage groups, right- vs. left-sided tumours as well as in microsatellite subgroups and finally in multivariate analyses incorporating all factors. Here, CDX2 is linked to neoplasm.