In this study, we evaluated the immunohistochemical expression of caudal-related homeobox transcription factor 2 (CDX2) in a large cohort of >1000 CRCs and correlated the results with staging parameters, microsatellite status and morphological parameters defined by the recent WHO classification (CRC subtypes, tumour budding, WHO grade). The gene discussed is CDX2; the disease is colorectal carcinoma.