For the ApcMin/+ model, whole-body Znf545 knockout mice (Znf545Δ/Δ) was crossed with ApcMin/+, a model of spontaneous CRC, to generate Znf545Δ/ΔApcMin/+, Znf545Δ/+ApcMin/+ and ApcMin/+ mice (Supplementary Fig. S1b). Here, ZFP82 is linked to colorectal carcinoma.