PER2 and oral cavity squamous cell carcinoma: Similar to BMAL1, a recent mouse tumor graft study with human oral squamous cell carcinoma (OSCC) cells suggested that PER2 is an effective chronomodulator of DNA damaging agents (e.g., oxaliplatin) since the efficacies of these drugs can be greatly boosted with timely administration at the peak of PER2 expression113.