As an additional tumor-controlling mechanism, the Lamia group has reported that CRY1 and/or CRY2 promote the degradation of cMYC, early 2 factors (E2F) family members, and tousled-like kinase 2 (TLK2) by recruiting these cell cycle-related oncogenic factors to the SCFFBXL3 ubiquitin-ligase complex42. The gene discussed is TLK2; the disease is neoplasm.