Epigenetic or genetic inactivation of Bmal1 and/or Clock has been shown to increase tumor proliferation or growth rates in several types of cancer, such as hematologic cancer25, colon cancer26, pancreatic cancer27, tongue squamous cell carcinoma (TSCC)28, breast cancer29, lung adenocarcinoma4, hepatocellular carcinoma (HCC)30, nasopharyngeal carcinoma (NPC)31, and glioblastoma (GBM)32. The gene discussed is CLOCK; the disease is hepatocellular carcinoma.