Moreover, Ke et al. have also confirmed that overexpression of CTHRC1 at translational level is significantly associated with the reduced overall survival (OS) duration of the non-small cell lung cancer (NSCLC) patients, but the potential causes behind CTHRC1 up-regulation was not elucidated in this study7. This evidence concerns the gene CTHRC1 and non-small cell lung carcinoma.