Western blotting verified the expression of CYP2R1 and CYP27A1, which confirmed that expression of CYP2R1 and CYP27A1 proteins in liver tissues of patients with BA was significantly lower than in the control group (CYP2R1: 0.67 ± 0.28 vs. 1.13 ± 0.43, P = 0.026; CYP27A1: 0.41 ± 0.15 vs. 0.68 ± 0.27, P = 0.035) (Fig. 2). The gene discussed is CYP27A1; the disease is breast angiosarcoma.