APOE and Alzheimer disease: None of the interactions was significant (p = 0.3, for PRS-Alz 4 × PGS-Int 7, p = 0.1, for PRS-Alz 5 × PGS-Int 7 and p = 0.9, for APOE × PGS-Int 7) (supplementary table S9) suggesting that APOE, and the polygenic contributions to AD and intelligence do not influence each other’s effect on cognitive decline.