When we dissected tumor tissues to examine TILs 14 days after therapy, intratumoral CD8+ T cells were proportionally increased only in the combination group (Fig. 6e); B16F10 tumors under the combinatory therapy contained the most CD8+ T cells producing effector cytokines IFN-γ and TNF-α (Fig. 6f). The gene discussed is CD8A; the disease is neoplasm.