We also noted a suggestive signal in tyrosine protein kinase Fes/Fps (FES) (OR = 2.00; 95% CI, 1.20–3.42; P = 2.5 × 10−4) which has previously been identified as a genome-wide significant loci for CAD in multiple studies (Supplementary Data 3). The gene discussed is FES; the disease is coronary artery disorder.