In fact, the effect size of RV-EXCALIBER’s RVGRS950, which conferred a 1.08-fold (95% CI, 1.04–1.11; P = 2.1 × 10−5) increased odds of CAD per SD change, represents a >20% increase relative to the predictive power of the RVGRS with the strongest CAD association according to TRAPD-derived odds ratios, which was found to confer a 1.06-fold (95% CI, 1.03–1.10; P = 4.4 × 10−4) increased odds of CAD per SD change (Supplementary Data 5). This evidence concerns the gene SSR4 and coronary artery disorder.