In fact, a total of 35 (excluding LDLR) of the 7146 genes assessed in the exome-wide rare variant association were found to harbor a genome-wide significant single nucleotide polymorphism for CAD (i.e., a CAD gene set) in the CARDIoGRAMplusC4D genome-wide association study. This evidence concerns the gene LDLR and coronary artery disorder.