When compared to the control cells with koC, NSD3 KO potently inhibited cell proliferation (EdU-positive nuclei ratio reduction, Fig. S2B) and migration (“Transwell” assays, Fig. S2C), while provoking apoptosis activation (TUNEL-positive nuclei ratio increase, Fig. S2D) in the established pancreatic cancer cells. This evidence concerns the gene IGF2BP3 and pancreatic neoplasm.