In PanCa-1 pancreatic cancer cells, NSD3 silencing (by shNSD3-S5, see Figs. 2 and 3) or KO (koNSD3, see Fig. 4) largely inhibited H3K36 dimethylation (H3K36me2) (Fig. 6A). Here, NSD3 is linked to familial pancreatic carcinoma.