ECHS1 and malignant colon neoplasm: Although several studies have shown that ECHS1 expression is absent in clear-cell renal-cell carcinoma (ccRCC) [28] or CRC [29], Western blot and IHC assays clearly showed that the expression of ECHS1 is highly expressed in colon-cancer cells and tissues and associated with advanced progression and poor prognosis based on our study.