PTPRD and non-small cell lung carcinoma: Here, we discovered that PTPRD phosphatase-mut could predict the outcomes in terms of ORR and PFS in discovery cohort and validate in 3 consolidated cohorts (total n=1920) that tissue or ctDNA PTPRD phosphatase-mut could predict ORR, PFS, and OS of ICIs, in non-squamous NSCLC, although it failed to predict OS in validation cohort 3.