CD274 and neoplasm: Apart from PD-L1 expression and TMB, recent studies have reported that specific gene alterations, such as KRAS/TP53 [15], STK11/LKB1 [16, 17], EGFR [17], POLD1/POLE [18], TET1 [19], EPHA [20], KEAP1 [21], and NOTCH [22], are linked to responses to ICIs by regulating the tumor immune microenvironment (TIME) and served as biomarkers to predict the outcomes of ICIs.