PTPRB and non-small cell lung carcinoma: We first investigated the hazard ratios (HRs) of PTPR mutations for PFS in NSCLC in the discovery cohort and found that PTPRB (HR=0.43, p=0.0432), PTPRD (HR=0.44, p=0.0178), and PTPRN2 (HR=0.30, p=0.0499) mutations were associated with longer PFS, while PTPRC mutations were linked to a shorter PFS (HR=181.9, p=0.0032) (Fig. 2a).