CAD-associated rs1004638 was associated with methylation of ANRIL. Compared with carriers of TT genotypes, AA and TT genotype carriers of rs1004638 had markedly elevated levels of methylation [ANRIL pos4 (p = 0.006) and pos8 (p = 0.019)]. The gene discussed is CDKN2B-AS1; the disease is coronary artery disorder.