Indeed, qPCR analyses revealed that only the combined inhibition of YAP and TAZ led to a prominent reduction of all investigated CIN signature genes, while the known YAP/TAZ target genes CYR61 and ANKRD1 were already consistently diminished after single YAP or TAZ inhibition (Fig. 4d/e). This evidence concerns the gene ANKRD1 and cervical squamous intraepithelial neoplasia.