MCM2 and cholangiocarcinoma: However, in all three CCA subtypes, nuclear YAP significantly correlated with the expression of the YAP target gene minichromosome maintenance complex component 2 (MCM2; iCCA: r = 0.23, pCCA: r = 0.2, dCCA: r = 0.31; all p ≤ 0.01).