IL4 and myasthenia gravis: Liu et al. [43] reported that both hypoxia and systemic inflammation have adverse effects on MG, and several studies have also demonstrated that chronic and intermittent hypoxia can provoke systemic inflammation by activating hypoxia inducible factor-1 (HIF-1), and increasing the expression of proinflammatory factors, such as interleukin (IL)-2, IL-4, and interferon (IFN)-γ [44–49].