TGFBI and neoplasm: Concurrently, since transforming growth factor‐β‐I (TGFβI) and plasminogen activator inhibitor 1 (PAI‐1) play a pivotal role in modulating ECM expression and remodeling and were identified in all the small‐EVs from tumor cells previously analyzed, we further studied their expression pre‐ and postchemotherapy in the three patients who were followed longitudinally (Fig. 7A).