CRP and obesity due to melanocortin 4 receptor deficiency: ,17,24 The results obtained by Danese et al.6showed that children with a very high level of social isolation (Table 3) were more likely to become depressed adults (relative risk [RR] 1.76; 95%CI 1.12–2.77), with a high risk of cardiac inflammation, with C-reactive protein (CRP)>3mg/L (RR 1.60; 95%CI 1.04–2.47) and with metabolic diseases such as obesity, hypertension, diabetes or hypercholesterolemia (RR 1.96; 95%CI 1.21–3.17), when compared with the reference adopted for children with a very low level of isolation (RR 1).