C5AR1 and COVID-19: At the same time, a population of cells lacking expression of typical DC markers such as CD1c, CD141, CD123, and CD11c but expressing HLADR and partially CD86 (Figs 2C, S1C, S1D and S1F), after that called non-DCs, was found to be significantly expanded within the Lin−HLA-DR+ CD88/89– CD16– fraction in patients with mild/moderate and severe COVID-19 compared to controls (Fig 2C).