When viewed in conjunction, (i) the absence of the GHR and SLC19A3 variants in the other affected cousins, (ii) the in-silico prediction indicating their deleteriousness as well as (iii) the involvement of both genes in syndromic forms of ID point to their implication in the severe cognitive impairment observed in this patient (TNDF182-6). This evidence concerns the gene GHR and Cognitive impairment.