As Figure 6D–6O revealed, low SERP1 expression was significantly associated with worse OS in SKCM patients both of gender, female (p = 0.009) or male (p = 0.006), race white (p = 0.001), age ≤ 60 (p = 0.005), T stage is T2-4 (p = 0.001), N stage is N1-3 (p = 0.008), M stage is 0 (p = 0.006), Pathologic Stage is II-IV (p = 0.007), without radiation therapy (p = 0.001), Tumor tissue site is on the trunk (p = 0.003), having melanoma ulceration (p = 0.003) and Melanoma Clark Level Stage is II-V (p = 0.012). The gene discussed is SERP1; the disease is neoplasm.