Moreover, a later study in lean mice suggested a role for adipocyte-specific PRDM16 in the regulation of adipose tissue sympathetic neurite density – making this an exciting candidate in the context of obesity-related sympathetic neuropathy, due to the spontaneous obesity accompanying an adipocyte-specific PRDM16 knockout (Cohen et al. 2014). Here, PRDM16 is linked to obesity due to melanocortin 4 receptor deficiency.