TGFB1 and aneurysm: In particular, TGF-β signaling was shown to stabilize aneurysm development by inducing fibroblasts to increase collagen production (Aparício et al. 2016) and a decrease in TGF-β signaling was demonstrated to significantly slow down the growth of a tissue-engineered vascular graft (Keshavarzian et al. 2019).