These variations in the FHR gene cluster and mutations in the FHR encoding genes in several glomerular disorders confirm that each single FHR protein, i.e., FHR1, FHR2, FHR3, FHR4 and FHR5 represents a major complement and immune regulator, e.g., FHR1 being an inflammatory mediator or competitor of Factor H in surface binding, or FHR5 as a complement activator propels cascade progression (Skerka et al. 2020; Chen et al. 2016; Irmscher et al. 2019). The gene discussed is CFHR5; the disease is glomerular disorder.