CFHR1 and hemolytic-uremic syndrome: The autoimmune form of aHUS include antibodies which bind to the C-terminal recognition region of Factor H. This form which is termed DEAP-HUS (DEficient for FHR1-FHR3 and Factor H Autoantibody Positive) affects about 10 to 15% of HUS patients (Zipfel et al. 2010a, b; Jozsi et al. 2008; Martin Merinero et al. 2021; Pesce et al. 2020).