The tumor ECM comprises of diverse components including proteoglycans such as syndecan, glypican, versican, aggrecan; polysaccharides such as hyaluronic acid; proteins such as collagen, fibulin, laminin, fibrillin, fibronectin, periostin, thrombospondin, and integrin (Nallanthighal et al. 2019). This evidence concerns the gene GPC1 and neoplasm.