Nude mouse strains expressing GFP under various endothelial-specific gene promoters such as Nestin regulatory protein, endothelial nitric oxide synthase (eNOS), and Tie2 have been successfully developed and are widely being used to study tumor vessel characteristics and screening anti-angiogenic drugs (Okabe et al. 1997; Staton et al. 2009). This evidence concerns the gene NOS3 and neoplasm.