CXCL8 and neoplasm: Similarly, Fischbach et al., used RGD (an integrin recognition site) bound alginate hydrogel to demonstrate enhanced secretion of IL-8 and VEGF by OSCC-3, MDA-MB-231 and glioblastoma cell line U87, whose blockage significantly reduced tumor angiogenesis and growth (Fischbach et al. 2009).