CBD also exerts its actions through other circuitry relevant to addictive disorder (e.g. 5HT1a, α7-nicotinic receptors), and some of its pharmacological effects such as reversing amphetamine-induced neuroinflammation and cognitive deficits, as well as alleviating mental disorder comorbidities (e.g. anxiety, depression) can be implied as a therapeutic benefit for amphetamine addiction (Calpe-López et al. 2019; Manzanares et al. 2018). This evidence concerns the gene HTR1A and mental disorder.