Recently, EWSR1 has been considered as a ‘hybrid’ gene involved in multiple mesenchymal tumor translocations, with evidence showing that it could be translocated and fused with many partner genes, including EWSR1-FLI1 and EWSR1-ERG in Ewing’s sarcoma [4,5], EWSR1-WT1 in desmoplastic small round cell tumors [6], EWSR1-DDIT3 in myxoid liposarcoma [7], EWSR1-CREB in angiomatoid fibrous histiocytoma [8] and EWSR1-ATF1 in clear-cell sarcoma-like tumors of the gastrointestinal tract. The gene discussed is EWSR1; the disease is histiocytoma, Angiomatoid fibrous.