Mice preconditioned with REM have been reported to display a much lower risk of myocardial injury following I/R procedures, whereas hyperglycemia-induced oxidative stress could diminish REM cardioprotection by damaging the Caveolin-3-regulated PI3K/Akt and JAK2/Stat3 signaling pathways [14]. This evidence concerns the gene JAK2 and Hyperglycemia.