JAK2 and Hyperglycemia: Moreover, mice preconditioned with REM have been reported to display a much lower risk of myocardial injury following I/R procedures, whereas hyperglycemia-induced oxidative stress could diminish REM cardioprotection by damaging the Caveolin-3-regulated PI3K/Akt and Janus kinase 2 (JAK2)/Stat3 signaling pathways [14].