PRL and amenorrhea: The incidence of prolactin-related adverse events was 22.6%, including hyperprolactinemia (9.4%), increased blood prolactin (9.4%), irregular menstruation (1.9%), amenorrhea-galactorrhea syndrome (0.9%), and galactorrhea (0.9%) (Table 6); however, there were no events leading to dose reduction or discontinuation of the study drug.